rs11052552 - CLEC2D - LINC02390
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls - Unknown journal (n.d.) · Unknown authors · PubMed 17554300
ABSTRACT: There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined ~2,000 individuals for each of 7 major diseases and a shared set of ~3,000 controls. Case-control comparisons identified 24 independent association signals at P<5×10-7: 1 in bipolar disorder, 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. On the basis of prior findings and replication studies thus-far completed, almost all of these signals reflect genuine susceptibility effects. We observed asso
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Type 1 diabetes screening and family risk assessment Moderate
Genetic variant increases Type 1 diabetes risk; clinician guidance optimizes screening strategy.
Discuss screening age, frequency, and family history implications with healthcare provider.
Screening
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glucose and HbA1c screening for Type 1 diabetes risk Moderate
rs11052552 is associated with Type 1 diabetes risk (OR=1.49, p=7.00e-7), warranting regular metabolic monitoring.
Annual fasting glucose and HbA1c; consider baseline screening if family history of Type 1 diabetes.