rs11049508 - CCDC91
Magnitude 2.2 · 1 study on file
Reported associations
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Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Unknown journal (n.d.) · Unknown authors · PubMed 40374629
ABSTRACT: Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Biobank (UKBB), it is now possible to study aging over time at genome-wide scale. In this work, we evaluated the suitability of competing models of change in realistic simulation settings, performed genome-wide association scans on simulation-validated measures of age-related deweekcline, and followed up with LD-score regression and Mendelian Randomization (MR) analyses. Focusing on global cognitive and physical function, we observed marked differences between baseline function (θ) and accelerated decline (Δ). Both outcomes showed distinct heritability levels (e.g., 31.38% versus 3.15%
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition for lower lung function Moderate
rs11049508 G allele associates with reduced baseline FEV in large population cohort
review genetic finding and discuss respiratory health monitoring plan
Exercise
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aerobic exercise for lung health Moderate
genetic predisposition to lower FEV suggests benefit from respiratory system conditioning
30 minutes moderate aerobic activity 5 or more days per week
Screening
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baseline spirometry assessment Moderate
rs11049508 G allele associates with reduced forced expiratory volume in large cohort
spirometry testing at baseline