rs11049144 - MANSC4

Magnitude 2.2 · 1 study on file

Reported associations

• GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification - Unknown journal (n.d.) · Unknown authors · PubMed 37679419

  ABSTRACT: Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations. We discovered 120 RG loci represented by 150 distinct signals, including 13 with sex-dimorphic effects, two cross-ancestry and seven rare frequency signals. Of these, 44 loci are new for glycemic traits. Regulatory, glycosylation and metagenomic annotations highlight ileum and colon tissues, indicating an

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