Expressive

rs11046703 - LINC02955

Magnitude 2.2 · 1 study on file

Reported associations

  • Femoral neck width genetic risk score is a novel independent risk factor for hip fractures - Unknown journal (n.d.) · Unknown authors · PubMed 38477772

    ABSTRACT: Abstract Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture prediction. Therefore, we investigated whether FNW is related to hip fracture risk independently of femoral neck bone mineral density (FN-BMD), using a genetic approach. FNW was derived from points automatically placed on the proximal femur using hip DXA scans from 38 150 individuals (mean age 63.8 yr, 48.0% males) in UK Biobank (UKB). Genome-wide association study (GWAS) identified 71 independent genome-wide significant FNW SNPs, comprising genes involved in cartilage differentiation, hedgehog, skeletal development, in contrast to SNPs identified by FN-BMD GWAS which primarily comprised runx1/Wnt signaling genes (MAGMA gene set analyses). FNW and FN-BMD SNPs were used to gene

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Hip fracture risk from bone geometry variant Moderate

    Genetic variant increases hip fracture risk through bone geometry mechanism independent of bone mineral density, warranting bone structure assessment

Lifestyle

  • Fall prevention measures for hip fracture risk Moderate

    Variant specifically increases hip fracture risk through geometry; fall prevention becomes especially relevant for this fracture type

    Consider home safety audit, balance training, vision and hearing screening

Screening

  • Hip fracture risk assessment with femoral neck width Moderate

    Variant increases femoral neck width, causally associated with increased hip and femoral neck fracture risk independent of bone density

    Discuss with healthcare provider about DXA hip imaging including femoral neck width measurement for fracture risk stratification