rs11045245 - PDE3A
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS on retinal vasculometry phenotypes - Unknown journal (n.d.) · Unknown authors · PubMed 36757925
ABSTRACT: The eye is the window through which light is transmitted and visual sensory signalling originates. It is also a window through which elements of the cardiovascular and nervous systems can be directly inspected, using ophthalmoscopy or retinal imaging. Measurements of ocular parameters may therefore offer important information on the physiology and homeostasis of these two important systems. Here we report the results of a genetic characterisation of retinal vasculature. Four genome-wide association studies performed on different aspects of retinal vasculometry phenotypes, such as arteriolar and venular tortuosity and width, found significant similarities between retinal vascular characteristics and cardiometabolic health. Our analyses identified 119 different regions of associati
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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cardiovascular risk profile and BP management strategy Moderate
PDE3A regulates vascular function; this variant causally affects diastolic blood pressure through vascular tortuosity pathways.
Discuss with primary care about individualized BP management given genetic risk.
Screening
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diastolic blood pressure Moderate
rs11045245 strongly associates with retinal arteriolar tortuosity, which causally elevates diastolic blood pressure via Mendelian randomization.
Regular BP monitoring from young adulthood; consider home BP monitoring.
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retinal vascular assessment at routine eye exams Moderate
rs11045245 is strongly associated with increased retinal arteriolar tortuosity, visible on fundus examination.
Mention genetic predisposition to ophthalmologist; ensure baseline retinal imaging.