Expressive

rs11044991 - TCP1P3 - LINC02468

Magnitude 2.2 · 2 studies on file

Reported associations

  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent - Unknown journal (n.d.) · Unknown authors · PubMed 30487518

    ABSTRACT: Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some

  • Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors - Unknown journal (n.d.) · Unknown authors · PubMed 33199917

    ABSTRACT: Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new genetic loci and the genetic architecture of intracranial aneurysms, we performed a cross-ethnic, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. A suggestive role for endothelial cells is found using gene mapping and heritability enrichment. Drug target enrichment shows pleiotropy between intracranial aneurysms and anti-epileptic and sex hormone drugs, providing insights into intracranial aneu

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • DASH diet and sodium restriction Moderate

    DASH diet lowers blood pressure through improved endothelial function; dietary sodium restriction reduces fluid retention and BP

    Adopt DASH diet emphasizing vegetables, fruits, whole grains, legumes; limit sodium to <2300 mg daily

Discuss with your doctor

  • Blood pressure management strategy with healthcare provider Moderate

    Genetic predisposition to elevated blood pressure increases risk of hypertension-related complications including intracranial aneurysm

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise directly lowers blood pressure and reduces endothelial dysfunction independent of weight loss

    150 minutes per week of moderate-intensity aerobic activity (e.g., brisk walking, cycling, swimming)

Screening

  • Blood pressure screening Moderate

    rs11044991 A allele associates with elevated mean arterial pressure, increasing cardiovascular disease risk

    Check blood pressure at least annually; measure every 6 months if baseline systolic ≥130 mmHg