Expressive

rs11043007 - MIR4686 - ASCL2

Magnitude 2.2 · 1 study on file

Reported associations

  • Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 25102180

    ABSTRACT: Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million geno

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • increase fiber-rich whole grains, limit refined carbs Moderate

    Whole grain diets improve glycemic control and insulin sensitivity in type 2 diabetes risk carriers

    Target 30+ grams fiber daily, replace refined grains with whole grains

Exercise

  • regular aerobic and strength training Moderate

    Physical activity improves insulin sensitivity and glucose control, reducing type 2 diabetes progression risk

    150 min/week moderate aerobic activity plus 2-3x/week resistance training

Lifestyle

  • maintain healthy weight (BMI 18.5-24.9) Moderate

    Weight management reduces insulin resistance and type 2 diabetes risk in genetic risk carriers

    Target 5-10% weight loss if overweight, maintain through diet and exercise

Screening

  • annual fasting glucose and HbA1c testing Moderate

    Early detection of impaired glucose tolerance or type 2 diabetes in carriers of this risk variant

    Annual screening starting at age 30-35