rs11039571 - PTPRJ - OR4B1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic predictors of fibrin D-dimer levels in healthy adults - Unknown journal (n.d.) · Unknown authors · PubMed 21502573

  ABSTRACT: Background Fibrin fragment D-dimer is one of several peptides produced when cross-linked fibrin is degraded by plasmin, and is the most widely-used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and Results A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21,052 European-ancestry adults. Plasma levels of D-dimer were measured independently in each of 13 cohorts. Each study analyzed the association between ~2.6 million genotyped and imputed variants across the 22 autosomal chromosomes and natural-log transformed D-dimer levels using linear regression in additive genetic models adjusted for age and sex. A

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