rs11039405 - NUP160
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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total cholesterol levels Moderate
T allele at rs11039405 associated with higher total cholesterol across 570,819 individuals in genome-wide association study
lipid panel every 1-2 years or per clinician recommendation; discuss if results are elevated
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weight and body mass index Moderate
T allele at rs11039405 associated with higher BMI across 607,406 individuals in genome-wide association study
annual or semi-annual BMI assessment; discuss weight management with clinician if trends upward