rs11039364 - FNBP4
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts - Unknown journal (n.d.) · Unknown authors · PubMed 30336701
ABSTRACT: Alcohol use disorders (AUD) are common conditions that have enormous social and economic consequences. We obtained quantitative measures using the Alcohol Use Disorder Identification Test (AUDIT) from two population-based cohorts of European ancestry: UK Biobank (UKB; N=121,604) and 23andMe (N=20,328) and performed a genome-wide association study (GWAS) meta-analysis. We also performed GWAS for AUDIT items 1-3, which focus on consumption (AUDIT-C), and for items 4-10, which focus on the problematic consequences of drinking (AUDIT-P). The GWAS meta-analysis of AUDIT total score identified 10 associated risk loci. Novel associations localized to genes including JCAD and SLC39A13; we also replicated previously identified signals in the genes ADH1B, ADH1C, KLB, and GCKR. The dime
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to alcohol use disorder Moderate
rs11039364 T allele is associated with increased alcohol consumption and alcohol use disorder risk in a large cohort study
discuss family history and personal alcohol use patterns with healthcare provider at next visit
Screening
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alcohol consumption patterns and quantity Moderate
T allele carriers show increased genetic predisposition to higher alcohol consumption and alcohol use disorder
regularly track consumption; use AUDIT-C screening if concerned about problematic use patterns