rs11038860 - CREB3L1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide meta-analyses of cross substance use disorders in diverse populations. - Molecular psychiatry (2026) · Lai D, Zhang M, Green N, Abreu M, Schwantes-An TH, Parker CC, Zhang S, Jin F, Sun A, Zhang P, Edenberg HJ, Liu Y, Foroud T · PubMed 41057643
Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studies have demonstrated the existence of genes shared across multiple SUDs, and identifying these SUD-shared genes is critical to developing novel prevention and treatment strategies. Here, we conducted the largest cross SUD meta-analysis to date to identify SUD-shared genes using samples genetically similar to 1000 Genomes Project European (1kg-EUR-like), African (1kg-AFR-like), and American mixed (1kg-AMR-like) populations. We defined variants that had the same direction of effects across different SUDs (i.e., concordant variants) as SUD-shared. In total, w
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk factors for substance use disorder Moderate
CREB3L1 rs11038860-T allele is genome-wide associated with substance use disorder
Discuss personal and family history of substance use, genetics, and screening appropriateness
Screening
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substance use patterns and risk Moderate
CREB3L1 rs11038860-T variant is associated with substance use disorder risk; monitoring may enable early intervention
Regular self-assessment and professional screening for substance use patterns and warning signs