rs11038294 - TRIM6-TRIM34, TRIM6

Magnitude 4.5 · 1 study on file

Reported associations

• Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking. - Alzheimer's & dementia : the journal of the Alzheimer's Association (2025) · Dacey R, Hou L, Gurnani A, Han X, Paller-Moore MR, Chung J, Durape S, Rosenthaler M, Uretsky M, Abdolmohammadi B, Lee AJ, Brickman AM, Hohman TJ, Cuccaro ML, Bennett DA, Crane PK, Kamboh MI, Kukull WA, Jun G, Stein TD, McKee AC, Haines JL, Pericak-Vance MA, Wang LS, Schellenberg GD, Mayeux R, Lunetta KL, Farrer LA, Mez J · PubMed 41268768

  Alzheimer's disease (AD) has genetic and environmental risk factors, including cigarette smoking. Gene-environment interactions may explain AD missing heritability. Lifetime smoking data from 22,032 European ancestry and 3126 African ancestry participants from the Alzheimer's Disease Genetic Consortium and the Framingham Heart Study were used to conduct genome-wide single nucleotide polymorphism (SNP)-by-smoking interaction and smoking-stratified association studies. For top-ranked loci, brain-derived bulk and single nuclei RNA-sequencing were used for differential expression and colocalization analyses. Among smokers only, there was a genome-wide significant association in the APAF1/ANKS1B region (rs12368451; odds ratio = 1.19, 95% confidence interval: [1.12, 1.27], p = 3.0 × 10 ). R

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