rs11035996 - LRRC4C
Magnitude 2.2 · 1 study on file
Reported associations
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DSP variants may be associated with longitudinal change in quantitative emphysema - Unknown journal (n.d.) · Unknown authors · PubMed 31324189
ABSTRACT: Background Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS) have identified multiple genetic factors associated with cross-sectional measures of quantitative emphysema, but the genetic determinants of longitudinal change in quantitative measures of emphysema remain largely unknown. Our study aims to identify genetic variants associated with longitudinal change in quantitative emphysema measured by computed tomography (CT) imaging. Methods We included current and ex-smokers from two longitudinal cohorts: COPDGene, a study of Non-Hispanic Whites (NHW) and African Americans (AA), and the Evaluation of COPD Longitudinally to
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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smoking if carrying T allele Moderate
T allele at rs11035996 in LRRC4C associated with faster lung density decline in smokers
Screening
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lung function screening if T allele carrier and smoker Moderate
Accelerated lung decline in T allele carriers suggests earlier onset of emphysema-related symptoms
discuss baseline and follow-up schedule with pulmonologist