rs11032840 - EHF - APIP

Magnitude 2.2 · 1 study on file

Reported associations

• Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study. - Thorax (2020) · Milne S, Li X, Hernandez Cordero AI, Yang CX, Cho MH, Beaty TH, Ruczinski I, Hansel NN, Bossé Y, Brandsma CA, Sin DD, Obeidat M · PubMed 32839289

  The anti-inflammatory pneumoprotein club cell secretory protein-16 (CC-16) is associated with the clinical expression of chronic obstructive pulmonary disease (COPD). We aimed to determine if there is a causal effect of serum CC-16 level on the risk of having COPD and/or its progression using Mendelian randomisation (MR) analysis. We performed a genome-wide association meta-analysis for serum CC-16 in two COPD cohorts (Lung Health Study (LHS), n=3850 and ECLIPSE, n=1702). We then used the CC-16-associated single-nucleotide polymorphisms (SNPs) as instrumental variables in MR analysis to identify a causal effect of serum CC-16 on 'COPD risk' (ie, case status in the International COPD Genetics Consortium/UK-Biobank dataset; n=35 735 COPD cases, n=222 076 controls) and 'COPD progression

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