Expressive

rs11032032 - PRRG4 - QSER1

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • body weight management to reduce hernia risk Moderate

    Obesity increases intra-abdominal pressure and substantially elevates hernia risk; weight control is particularly important given this genetic predisposition

    Maintain BMI 18.5-24.9; if overweight, pursue gradual weight loss through balanced diet and regular physical activity

  • heavy lifting and strenuous straining Moderate

    Elevated intra-abdominal pressure from heavy lifting significantly increases hernia risk, and this variant elevates baseline inguinal hernia susceptibility 1.11-fold

    Avoid lifting objects over 10 kg when possible; use proper lifting technique; ask for assistance with heavy items

Screening

  • inguinal hernia development and symptoms Moderate

    This genetic variant increases inguinal hernia risk approximately 1.11-fold per risk allele; early detection enables timely surgical intervention and better outcomes

    Self-examine groin area monthly for bulges or asymmetry; report new groin pain or bulging sensations to physician promptly