Expressive

rs11031926 - CCDC73

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • heavy lifting and forceful straining Moderate

    Acute increase in intra-abdominal pressure during heavy lifting or straining can precipitate hernia in genetically predisposed individuals.

    Avoid lifting more than 30-50 lbs; use proper body mechanics; minimize prolonged straining.

Lifestyle

  • maintain healthy body weight Moderate

    Increased abdominal weight raises intra-abdominal pressure, substantially increasing hernia risk in genetically predisposed individuals.

    Target BMI 18.5-24.9 kg/m2; gradual weight loss if currently overweight.

Screening

  • inguinal hernia symptoms Moderate

    Genetic variant is significantly associated with increased inguinal hernia risk; early detection allows timely intervention.

    Seek medical evaluation for groin pain, bulging, or discomfort with lifting.