rs11031737 - THEM7P - WT1
Magnitude 2.2 · 2 studies on file
Reported associations
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction - Unknown journal (n.d.) · Unknown authors · PubMed 32439900
ABSTRACT: The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for
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Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups - Unknown journal (n.d.) · Unknown authors · PubMed 40050615
ABSTRACT: Uterine leiomyomata or fibroids are highly heritable, common, and benign tumors of the uterus with poorly understood etiology. Previous GWAS have reported 72 associated genes but included limited numbers of non-European individuals. Here, we identify 11 novel genes associated with fibroids across multi-ancestry and ancestry-stratified GWAS analyses. We replicate a known fibroid GWAS gene in African ancestry individuals and estimate the SNP-based heritability of fibroids in African ancestry populations as 15.9%. Using genetically predicted gene expression and colocalization analyses, we identify 46 novel genes associated with fibroids. These genes are significantly enriched in cancer, cell death and survival, reproductive system disease, and cellular growth and proliferation netwo
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Pelvic ultrasound screening for uterine fibroids High
A risk allele is associated with significantly elevated uterine fibroid risk, particularly in reproductive-age individuals
Baseline pelvic ultrasound if not recently obtained; discuss periodic monitoring with gynecologist
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Baseline electrocardiogram and periodic cardiac monitoring Moderate
G risk allele is associated with prolonged PR interval, indicating atrioventricular conduction delay that may increase cardiac arrhythmia risk
Baseline ECG; consider repeating every 2-3 years or if symptoms develop