Expressive

rs11031715 - THEM7P - WT1

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic predisposition to inguinal hernia Moderate

    GWAS evidence identifies substantially elevated hernia risk (p<1e-10) from this variant, warranting individualized clinical guidance

Lifestyle

  • healthy body weight and BMI Moderate

    Excess intra-abdominal fat increases pressure on the inguinal canal; weight management is especially important with genetic predisposition

    Maintain BMI <25 kg/m2 through balanced nutrition and regular moderate exercise

  • heavy lifting and intense abdominal straining Moderate

    Heavy lifting and straining increase intra-abdominal pressure, which elevates mechanical stress on the inguinal canal in genetically predisposed individuals

    Avoid lifting heavy objects; use proper lifting technique (bend knees, keep back straight); avoid prolonged straining

Screening

  • inguinal hernia symptoms Moderate

    Genetic variant rs11031715 (G allele) confers approximately 10% increased hernia risk (OR 1.1), making early detection critical

    Seek medical evaluation for any groin bulge, pain with lifting/straining, or persistent groin discomfort