rs11030024 - LGR4-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria - Unknown journal (n.d.) · Unknown authors · PubMed 31511532
ABSTRACT: Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through d
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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urinary albumin-to-creatinine ratio Moderate
rs11030024 T allele is associated with elevated urinary albumin-to-creatinine ratio, an early marker of kidney dysfunction.
Check UACR annually or at routine physical examinations.