rs11029956 - CCDC34
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608
ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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cardiovascular risk stratification Moderate
Genetic marker for increased subclinical atherosclerosis warrants professional cardiovascular risk assessment
Lifestyle
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cardiovascular disease prevention Moderate
Genetic association with atherosclerotic burden marker indicates elevated cardiovascular disease risk requiring preventive management
Maintain regular aerobic exercise (150+ minutes weekly) and Mediterranean-style diet
Screening
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carotid intima-media thickness screening Moderate
rs11029956-A is associated with increased carotid intima-media thickness, a marker of subclinical atherosclerosis
Discuss with cardiologist or internist about baseline carotid ultrasound assessment