rs11027857 - LINC02686 - Y_RNA

Magnitude 2.2 · 1 study on file

Reported associations

• Biological Insights From 108 Schizophrenia-Associated Genetic Loci - Unknown journal (n.d.) · Unknown authors · PubMed 25056061

  ABSTRACT: Summary Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here, we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain providing biological plausibility for the findings. Many findings have the potential to provide entirely novel insights into aetiology, but associations at DRD2 and multiple genes involved in glutamatergic neurotransmission highlight molec

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