rs11025915 - NELL1

Magnitude 2.8 · 1 study on file

Reported associations

• Bone mineral density in children with acute lymphoblastic leukemia - Unknown journal (n.d.) · Unknown authors · PubMed 29266176

  ABSTRACT: BACKGROUND Children with acute lymphoblastic leukemia (ALL) can develop reduced bone mineral density (BMD). However, data from patients treated on a frontline regimen without cranial irradiation are limited, and no genome-wide analysis has been reported. METHODS Lumbar BMDs were evaluated by quantitative computed tomography at diagnosis, after 120 weeks of continuation therapy, and after 2 years off therapy in pediatric ALL patients (aged 2-18 years at diagnosis) treated on the St. Jude Total XV protocol. Clinical, pharmacokinetic, and genetic risk factors associated with decreased BMD Z-scores were evaluated. RESULTS The median BMD Z-score in 363 patients was 0.06 at diagnosis, declined to −1.08 at week 120, but partly recovered to −0.72 after 2 years off therapy; BMD in p

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