rs11025608 - PRMT3 - HMGB1P40

Magnitude 2.2 · 1 study on file

Reported associations

• Carotid Intima-Media Thickness - Unknown journal (n.d.) · Unknown authors · PubMed 31801372

  ABSTRACT: Supplemental Digital Content is available in the text. Objective: Atherosclerosis is the underlying cause of most cardiovascular disease, but mechanisms underlying atherosclerosis are incompletely understood. Ultrasound measurement of the carotid intima-media thickness (cIMT) can be used to measure vascular remodeling, which is indicative of atherosclerosis. Genome-wide association studies have identified many genetic loci associated with cIMT, but heterogeneity of measurements collected by many small cohorts have been a major limitation in these efforts. Here, we conducted genome-wide association analyses in UKB (UK Biobank; N=22 179), the largest single study with consistent cIMT measurements. Approach and Results: We used BOLT-LMM software to run linear regression of cIMT in

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