Expressive

rs11025109 - NAV2-IT1, NAV2

Magnitude 4.5 · 1 study on file

Reported associations

  • A molecular pathway analysis informs the genetic risk for arrhythmias during antipsychotic treatment. - International clinical psychopharmacology (2018) · Drago A, Kure Fischer E · PubMed 29064910

    Arrhythmias are a frequent and potentially fatal side effect of antipsychotic treatment. Strict ECG monitoring and clinical interviews are the standards used to prevent arrhythmias. A biologic predictive tool is missing. The identification of a genetic makeup at risk of antipsychotic-induced arrhythmias is the aim of the present investigation. The aim of this study was to identify a molecular pathway enriched in single nucleotide polymorphisms associated with antipsychotic-induced QTc modifications. In total, 661 schizophrenic individuals from the CATIE study, M=486 (73.52%), mean age=40.92±11.02, were included. QTc variation was measured as a phase-specific change-created variable. A nested mixed regression for a repeated-measures model served in R for the analysis of the clinical and tr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic risk for antipsychotic-induced QT prolongation Moderate

    NAV2 variant increases susceptibility to QTc changes with antipsychotic treatment

    • GWAS_CATALOG:29064910

Drug interactions

  • other medications that prolong QTc interval Moderate

    Combined QT-prolongation risk from genetic predisposition and additional QT-prolonging drugs

    Review all current and planned medications for QTc-prolonging effects

    • GWAS_CATALOG:29064910

Screening

  • QTc interval during antipsychotic treatment Moderate

    A allele carriers show greater QTc prolongation with antipsychotics

    ECG at 1-2 weeks, then monthly during first 3 months, then quarterly or as directed

    • GWAS_CATALOG:29064910
  • baseline ECG before antipsychotic initiation Moderate

    rs11025109 A allele increases QTc interval prolongation in response to antipsychotics

    Complete 12-lead ECG before starting antipsychotics to establish baseline

    • GWAS_CATALOG:29064910