rs11021842 - GALNT18
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association meta-analysis identifies two novel loci associated with dental caries - Unknown journal (n.d.) · Unknown authors · PubMed 39192244
ABSTRACT: Background Tooth loss significantly impacts oral function and overall health deterioration. Dental caries and periodontal disease are major contributors to tooth loss, emphasizing the critical need to prevent these conditions. Genetic studies have played a crucial role in deepening our understanding of the underlying mechanisms of these diseases. While large-scale genome-wide association studies (GWAS) on dental caries and periodontal disease have been conducted extensively, research focusing on Asian populations remains limited. Given substantial genetic and lifestyle variations across ethnicities, conducting studies across diverse populations is imperative. This study aimed to uncover new insights into the genetic mechanisms of these diseases, contributing to broader knowledge
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Limit refined sugar and acidic beverages Moderate
Increased genetic susceptibility to caries amplifies harm from dietary risk factors
Reduce added sugars to <50g daily, minimize sugary drinks and acidic beverages
Discuss with your doctor
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Discuss personalized caries prevention strategy Moderate
Genetic predisposition warrants clinical risk assessment and individualized prevention plan
Share SNP information with dentist to inform prevention approach
Lifestyle
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Optimize oral hygiene with fluoride toothpaste Moderate
Genetic caries risk requires more rigorous preventive practices
Brush 2 times daily with fluoride toothpaste, floss daily, consider electric toothbrush
Screening
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Increase dental screening frequency Moderate
GALNT18 variant rs11021842 is associated with substantially increased dental caries risk
Schedule dental checkups every 3-4 months instead of standard 6-12 months