rs11021056 - LNCRNA-IUR

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia - Unknown journal (n.d.) · Unknown authors · PubMed 39189922

  ABSTRACT: Key Points The allele frequency of variants in genes linked to Wnt/β-catenin signaling differed between pediatric ITP and control cohorts. No genetic variants met genome-wide significance in a comparison of spontaneously resolving ITP and chronic ITP. Visual Abstract Abstract Through the use of genetic sequencing, molecular variants driving autoimmunity are increasingly identified in patients with chronic and refractory immune cytopenias. With the goal of discovering genetic variants that predispose to pediatric immune thrombocytopenia (ITP) or increase risk for chronic disease, we conducted a genome-wide association study in a large multi-institutional cohort of pediatric patients with ITP. A total of 591 patients were genotyped using an Illumina Global Screening Array BeadChip

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