rs11020821 - C11orf97 - PIWIL4

Magnitude 2.8 · 1 study on file

Reported associations

• GENOMIC ASSOCIATION ANALYSIS IDENTIFIES MULTIPLE LOCI INFLUENCING ANTIHYPERTENSIVE RESPONSE TO AN ANGIOTENSIN II RECEPTOR BLOCKER - Unknown journal (n.d.) · Unknown authors · PubMed 22566498

  ABSTRACT: To identify genes influencing blood pressure response to an angiotensin II receptor blocker, single nucleotide polymorphisms identified by genome-wide association analysis of the response to candesartan were validated by opposite direction associations with the response to a thiazide diuretic, hydrochlorothiazide. 198 White and 193 African Americans with primary hypertension were sampled from opposite tertiles of the race-sex-specific distributions of age-adjusted diastolic blood pressure response to candesartan. 285 polymorphisms associated with the response to candesartan at p<10−4 in Whites. 273 of the 285 polymorphisms, which were available for analysis in a separate sample of 196 Whites, validated for opposite direction associations with the response to hydrochlorothiazide

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