rs11020123 - SNRPGP16 - MTNR1B

Magnitude 4.5 · 1 study on file

Reported associations

• Pilot GWAS of caries in African-Americans shows genetic heterogeneity - Unknown journal (n.d.) · Unknown authors · PubMed 31533690

  ABSTRACT: Background Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African Americans has not been performed previously. Methods We performed exploratory GWAS of dental caries in 109 African American adults (age > 18) and 96 children (age 3-12) from the Center for Oral Health Research in Appalachia (COHRA1 cohort). Caries phenotypes (DMFS, DMFT, dft, and dfs indices) assessed by dental exams were tested for association with 5 million genotyped or imputed single nucleotide polymorphisms (SNPs), separately in

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