rs1101999 - PYHIN1

Magnitude 2.0 · 1 study on file

Reported associations

• Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations - Unknown journal (n.d.) · Unknown authors · PubMed 21804549

  ABSTRACT: Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies (GWAS) of asthma in 5,416 asthma cases representing European Americans, African Americans/African Caribbeans, and Latinos, and replicated five regions among the most significant signals in 12,649 individuals from the same ethnic groups. Four were at previously reported loci on 17q21, and near the IL1RL1, TSLP, and IL33, genes, but we report for the first time that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a novel association with asthma in the PYHIN1, gene that was specific to individuals of African descent (p=3.9×10−9). These results sugge

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