Expressive

rs11018569 - TYR - NOX4

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to insomnia and treatment options Moderate

    Strong GWAS evidence for genetic contribution to insomnia risk supports evaluation for personalized medical management options

Lifestyle

  • Structured sleep hygiene and sleep optimization Moderate

    Genetic predisposition to insomnia suggests heightened sleep system sensitivity; consistent sleep practices may substantially improve outcomes

    Consistent sleep schedule, cool dark bedroom, limit afternoon caffeine, 30-min pre-bed wind-down

Screening

  • Sleep quality and insomnia symptoms Moderate

    A allele carriers have significantly increased genetic predisposition to insomnia; proactive monitoring enables early intervention

    Screen at baseline and monitor for insomnia symptoms annually or when sleep problems arise