Expressive

rs11018488 - GRM5 - TYR

Magnitude 2.2 · 1 study on file

Reported associations

  • Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 32060260

    ABSTRACT: Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability scale. Genetic correlations with body mass index, alcohol intake, smoking, schizophrenia, anorexia nervosa and neuroticism are observed. Gene-based associations identify 173 genes, including DLEU7, MSRB3 and POC5, highlighting genes expressed in the brain, cerebellum, lungs, blood and oesophagus. We use polygenic scores (PGS) to predict recent snoring and probable obstructive sleep apnoea (OSA) in an independent Australian sample (n ~ 8000). Mendelian random

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Assess snoring pattern and sleep quality Moderate

    Genetic variant associated with snoring requires clinical assessment to detect potential obstructive sleep apnea and cardiovascular consequences

Lifestyle

  • Nasal airway clearance Moderate

    Nasal obstruction exacerbates snoring; maintaining clear nasal airway reduces snoring severity in genetically susceptible individuals

    Use saline nasal rinse or spray as needed; consider nasal strips during sleep

  • Sleep in side position Moderate

    Genetic predisposition to snoring may be mitigated by lateral positioning which reduces upper airway collapse during sleep

    Sleep on left or right side rather than supine when possible

Screening

  • Sleep apnea screening discussion Moderate

    rs11018488 A allele is associated with increased snoring susceptibility; snoring is a primary symptom and predictor of obstructive sleep apnea

    Discuss sleep apnea screening options with physician, including polysomnography or home sleep apnea testing