Expressive

rs11014267 - CACNB2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Insights from a Large-Scale Whole Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension - Unknown journal (n.d.) · Unknown authors · PubMed 35652341

    ABSTRACT: Background: The availability of whole genome sequencing data in large studies has enabled the assessment of coding and non-coding variants across the allele frequency spectrum for their associations with blood pressure. Methods: We conducted a multi-ancestry whole genome sequencing analysis of blood pressure among 51,456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program participants (stage-1). Stage-2 analyses leveraged array data from UK Biobank (N=383,145), Million Veteran Program (N= 318,891), and Reasons for Geographic and Racial Differences in Stroke (N=10,643) participants, along with whole exome sequencing data from UK Biobank (N=199,631) participants. Results: Two blood pressure signals achieved genome-wide significance in meta-analyses of

  • Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878

    ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/

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