Expressive

rs11010734 - NAMPTP1 - Y_RNA

Magnitude 4.5 · 1 study on file

Reported associations

  • The first broad replication study of SNPs and a pilot genome-wide association study for androgenetic alopecia in Asian populations. - Journal of cosmetic dermatology (2022) · Kim IY, Kim JH, Choi JE, Yu SJ, Kim JH, Kim SR, Choi MS, Kim MH, Hong KW, Park BC · PubMed 35754308

    Many candidate genes for androgenetic alopecia (AGA) have been identified in studies of the Caucasians and some Asian populations. This study aimed to confirm the known susceptibility genes reported in previous studies and find additional candidate genes for high-risk individuals for AGA in Korean population. We recapitulated the previously reported SNPs and identified the novel Korean AGA risk genetic variants using a Korean hospital-based AGA case and control samples. The population was consisting of 494 individuals (275 AGA cases and 146 controls). Using the 800 K SNPs of precision medical research array (PMRA SNP microarray chip) and imputation-based SNPs, 12 previous GWAS reports for AGA and a total of 62 160 SNPs were examined in our study samples. Also, we conducted the genome-w

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • androgenetic alopecia risk and management options Moderate

    rs11010734 carrier status supports informed discussion of genetic risk and available interventions including finasteride and minoxidil

    schedule dermatology consultation if concerned about hair loss or prevention strategies

Screening

  • baseline dermatological assessment Moderate

    rs11010734 C allele confers 3-fold increased androgenetic alopecia risk in Asian populations, warranting baseline documentation of hair and scalp status

    schedule appointment in 20s-30s if not already done

  • hair thinning or scalp density changes Moderate

    genetic predisposition to androgenetic alopecia necessitates awareness for early detection of disease onset or progression

    observe and track any changes; photograph baseline and annually if changes noted