Expressive

rs11006914 - MPP7

Magnitude 2.2 · 1 study on file

Reported associations

  • Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density☆ - Unknown journal (n.d.) · Unknown authors · PubMed 29499414

    ABSTRACT: In the present study, aiming to identify loci associated with osteoporosis, we conducted a joint association study of 2 independent genome-wide association meta-analyses of femoral neck and lumbar spine bone mineral densities (BMDs): 1) an in-house study of 6 samples involving 7484 subjects, and 2) the GEFOS-seq study of 7 samples involving 32,965 subjects. The in-house samples were imputed by the 1000 genomes project phase 3 reference panel. SNP-based association test was applied to 7,998,108 autosomal SNPs in each meta-analysis, and for each SNP the 2 association signals were then combined for joint analysis and for mutual replication. Combining the evidence from both studies, we identified 2 novel loci associated with BMDs at the genome-wide significance level (α = 5.0 × 10

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Calcium-rich foods Moderate

    Genetic predisposition to lower BMD requires robust calcium intake to support bone formation and maintenance.

    Target 1000-1200 mg per day from dairy, leafy greens, and fortified foods.

Discuss with your doctor

  • Bone health management strategy Moderate

    Genetic predisposition to lower BMD warrants proactive clinical assessment and personalized prevention strategy.

Exercise

  • Weight-bearing and resistance exercise Moderate

    Mechanical loading is a primary stimulus for bone formation; particularly important given genetic predisposition to lower BMD.

    30 minutes of weight-bearing or resistance exercise 3-5 times per week.

Screening

  • Bone mineral density screening Moderate

    Genetic association with lower lumbar spine BMD indicates need for early and regular osteoporosis surveillance.

    Consider DEXA scan starting at age 40 or earlier with risk factors; repeat every 1-2 years if abnormal.

Supplements

  • Vitamin D supplementation Moderate

    Vitamin D is essential for calcium absorption; genetic BMD predisposition may necessitate optimization.

    Check serum 25-OH vitamin D; supplement to maintain 30-50 ng/mL.