rs11006263 - BICC1
Magnitude 2.2 · 1 study on file
Reported associations
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Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661
ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular structured physical activity Low
Exercise mitigates genetic obesity risk via energy expenditure and metabolism
Aim for 150 minutes moderate aerobic plus 2x per week resistance training
Lifestyle
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Awareness of caloric balance Low
Genetic obesity risk may be moderated by dietary energy balance
Monitor caloric intake and food quality; seek dietitian if weight management needed
Screening
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Weight and metabolic trait monitoring Moderate
rs11006263 G allele associates with increased obesity-related traits
Regular BMI and weight assessment; metabolic panel every 1-2 years