rs11006002 - MRPS35P3 - IPMK

Magnitude 2.2 · 1 study on file

Reported associations

• A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin - Unknown journal (n.d.) · Unknown authors · PubMed 26545630

  ABSTRACT: Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However the role of CLU on AD pathogenesis is not totally understood. We used CSF and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not plasma, CLU levels were significantly associated with AD status and CSF tau/Aβ ratio, and highly correlated with CSF apolipoprotein E (APOE) levels. Several loci showed almost genome-wide significant associations including LINC00917 (p=3.98×10−7) and interleukin 6 (IL6, p=9.94×10−6, in the entire dataset and in the APOE ε4- individuals p=7.40×10−8). Gene-ontology analyses suggest that CSF CLU levels may be associated with wound healing and immune response which supports previo

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