rs11006 - SLC37A4, TRAPPC4

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome. - Nature genetics (2021) · Rühlemann MC, Hermes BM, Bang C, Doms S, Moitinho-Silva L, Thingholm LB, Frost F, Degenhardt F, Wittig M, Kässens J, Weiss FU, Peters A, Neuhaus K, Völker U, Völzke H, Homuth G, Weiss S, Grallert H, Laudes M, Lieb W, Haller D, Lerch MM, Baines JF, Franke A · PubMed 33462482

  The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory , neurologic and neoplastic diseases . Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain . Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition . In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition. Further analyses confirm the identified associations of ABO histo-blood groups and FUT2 secretor status with Bacteroides and Faecalibacterium spp. Mendelian randomiza

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.