rs11001788 - LRMDA
Magnitude 2.2 · 1 study on file
Reported associations
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Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036
ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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hip joint strength and flexibility training Moderate
Strengthening periarticular muscles reduces abnormal joint loading and supports cartilage health
150 min moderate activity weekly plus 2x/week hip and core strengthening exercises
Lifestyle
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weight management to reduce hip joint stress Moderate
Excess body weight increases mechanical stress on hip joints and accelerates cartilage degeneration
Maintain BMI < 25 through balanced nutrition and regular physical activity
Screening
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baseline hip joint imaging at age 40 Moderate
Early detection of osteoarthritis changes enables preventive intervention before symptomatic disease
Consider baseline hip imaging (X-ray or MRI) at age 40, then every 5-10 years or if symptoms