rs10996471 - MYL6P3 - LINC01515

Magnitude 2.2 · 1 study on file

Reported associations

• Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men - Unknown journal (n.d.) · Unknown authors · PubMed 40316537

  ABSTRACT: Given the various roles of testosterone in men's health, we conducted a multi-ancestral genetic analysis of total testosterone, free testosterone, SHBG, and hypogonadism in men within the Million Veteran Program (MVP). Here we identified 157 significant testosterone genetic variants, of which 8 have significant ancestry-specific associations. These variants implicate several genes, including SERPINF2, PRPF8, BAIAP2L1, SHBG, PRMT6, and PPIF, related to liver function. Genetic regulators of testosterone have cell type-specific effects in the testes, liver, and adrenal gland and are associated with disease risk. We conducted a meta-analysis amongst ancestry groups to identify 188 variants significantly associated with testosterone, of which 22 are novel associations. We constructe

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