Expressive

rs10995385 - EGR2 - RNU6-543P

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • high-impact activities that stress knees Low

    High-impact activities like running and jumping place excessive mechanical stress on genetically vulnerable knee joints, potentially accelerating OA onset

  • low-impact aerobic activity for joint protection Moderate

    Regular low-impact exercise maintains muscle support and cartilage health without excessive mechanical stress on genetically vulnerable knee joints

    150 minutes per week of swimming, cycling, or walking

Lifestyle

  • maintain healthy body weight to reduce knee loading Moderate

    Elevated body weight increases mechanical stress on knee joints, accelerating osteoarthritis progression in genetically susceptible individuals

    Target BMI 18.5-24.9 kg/m2

Screening

  • knee health assessment for osteoarthritis Moderate

    Variant rs10995385 shows strong GWAS association with knee osteoarthritis (p=2e-12, n=1316500); early monitoring enables intervention before significant joint damage occurs

    Baseline assessment at age 40-50, then every 1-2 years or if symptoms develop