rs10995181 - ZNF365 - LINC02929
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk - Unknown journal (n.d.) · Unknown authors · PubMed 33037222
ABSTRACT: Mammographic density (MD) phenotypes are strongly associated with breast cancer risk and highly heritable. In this GWAS meta-analysis of 24,192 women, we identify 31 MD loci at P < 5 × 10−8, tripling the number known to 46. Seventeen identified MD loci also are associated with breast cancer risk in an independent meta-analysis (P < 0.05). Mendelian randomization analyses show that genetic estimates of dense area (DA), nondense area (NDA), and percent density (PD) are all significantly associated with breast cancer risk (P < 0.05). Pathway analyses reveal distinct biological processes involving DA, NDA and PD loci. These findings provide additional insights into the genetic basis of MD phenotypes and their associations with breast cancer risk. Mammographic densi
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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enhanced breast cancer screening strategy Moderate
rs10995181 variant associated with increased mammographic breast density, an independent breast cancer risk factor requiring personalized risk assessment
discuss baseline and interval mammography recommendations with healthcare provider