rs10995170 - ZNF365

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of intelligence: additive effects of novel brain expressed genes. - Journal of the American Academy of Child and Adolescent Psychiatry (2012) · Loo SK, Shtir C, Doyle AE, Mick E, McGough JJ, McCracken J, Biederman J, Smalley SL, Cantor RM, Faraone SV, Nelson SF · PubMed 22449649

  The purpose of the present study was to identify common genetic variants that are associated with human intelligence or general cognitive ability. We performed a genome-wide association analysis with a dense set of 1 million single-nucleotide polymorphisms (SNPs) and quantitative intelligence scores within an ancestrally homogeneous family sample of 656 individuals with at least one child affected by attention-deficit/hyperactivity disorder (ADHD). Haplotype trend regression analysis with sliding four-SNP windows identified haplotypes of genome-wide significance in genes involved in synaptic signaling (KIF16B; p = 1.27E-08) and neurodevelopment (PAX5; p = 3.58E-08), and highlight findings from a recent genetic study of cognitive ability (RXRA; p = 7.7E-08; GYPC; p = 2.5E-07). Further inter

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