rs10993435 - AOPEP

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas - Unknown journal (n.d.) · Unknown authors · PubMed 38190104

  ABSTRACT: Summary Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidney function. To address this bias, we conducted a large meta-analysis of GWASs of estimated glomerular filtration rate (eGFR) in 145,732 AFR and AMS individuals. We identified 41 loci at genome-wide significance (p < 5 × 10−8), of which two have not been previously reported in any ancestry group. We integrated fine-mapped loci with epigenomic and transcriptomic resources to highlight potential effector genes relevant to kidney physiology and disease, and reveal key regulatory elements and pathways involved in renal function and d

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