rs10993397 - AOPEP

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations - Unknown journal (n.d.) · Unknown authors · PubMed 26284813

  ABSTRACT: Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels. Three loci reach genome-wide significance in the case-control meta-analysis, two novel loci mapping to chr 8p32.1 and chr 11p14.1, and a chr 9q22.32 locus previously found in Chines

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