rs10993160 - ZNF169 - NUTM2F

Magnitude 2.2 · 1 study on file

Reported associations

• Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations - Unknown journal (n.d.) · Unknown authors · PubMed 22344221

  ABSTRACT: Obesity is a disorder with complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index (BMI), the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here, we report a genome-wide association study (GWAS) and replication studies with 62,245 East Asian subjects, which identified two novel BMI-associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 × 10−11) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 × 10−9), as well as previously reported loci (the SEC16B, BDNF, FTO, MC4R, and GIPR loci; P < 5.0 × 10−8). We subsequently performed gene-gene interaction analysis and identified an interaction (P = 2.0 × 10−8) between

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