rs10993000 - LINC01508
Magnitude 2.8 · 1 study on file
Reported associations
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Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies - Unknown journal (n.d.) · Unknown authors · PubMed 36802911
ABSTRACT: Background: Hypertension imposes substantial health and economic burden worldwide. Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, causing cardiovascular events at higher risk compared with essential hypertension. However, the germline genetic contribution to the susceptibility of PA has not been well elucidated. Method: We conducted a genome-wide association analysis of PA in the Japanese population and a cross-ancestry meta-analysis combined with UK Biobank and FinnGen cohorts (816 PA cases and 425 239 controls) to identify genetic variants that contribute to PA susceptibility. We also performed a comparative analysis for the risk of 42 previously established blood pressure-associated variants between PA and hypertension with the adjus
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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primary aldosteronism risk and screening timeline Moderate
Carrier of rs10993000 C-allele shows 1.46-fold increased primary aldosteronism risk.
Screening
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aldosterone-renin ratio screening Moderate
Genetic variant associated with increased primary aldosteronism risk; aldosterone-renin ratio is standard diagnostic test.
Discuss with physician; may include supine aldosterone and plasma renin activity testing.
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blood pressure monitoring Moderate
Primary aldosteronism presents with hypertension in most cases; genetic risk increases susceptibility.
Regular home or clinical blood pressure checks; track readings for trends.