rs10991823 - LINC02937

Magnitude 2.8 · 1 study on file

Reported associations

• Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women - Unknown journal (n.d.) · Unknown authors · PubMed 32227112

  ABSTRACT: Abstract Glycosuria is a condition where glucose is detected in urine at higher concentrations than normal (i.e. not detectable). Glycosuria at some point during pregnancy has an estimated prevalence of 50% and is associated with adverse outcomes in both mothers and offspring. Little is currently known about the genetic contribution to this trait or the extent to which it overlaps with other seemingly related traits, e.g. diabetes. We performed a genome-wide association study (GWAS) for self-reported glycosuria in pregnant mothers from the Avon Longitudinal Study of Parents and Children (cases/controls = 1249/5140). We identified two loci, one of which (lead SNP = rs13337037; chromosome 16; odds ratio of glycosuria per effect allele: 1.42; 95% CI: 1.30, 1.56; P = 1.97

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