rs10991100 - SMC2-DT
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans - Unknown journal (n.d.) · Unknown authors · PubMed 35501403
ABSTRACT: Metal elements are present in the human body, and their levels in the blood have important impacts on health. In this study, 2488 Chinese individuals were included in a genome-wide association study of 21 serum metal levels, with approximately 179,000 East Asian individuals in a bidirectional two-sample Mendelian randomization (MR) analysis, and 628,000 Europeans in a two-sample MR analysis. We identified two single nucleotide polymorphisms (SNPs) rs35691438 and rs671 that were significantly associated with serum copper levels (SCLs). The bidirectional two-sample MR analysis in the East Asian population showed that gamma-glutamyl transpeptidase levels have a causal effect on SCLs. SCLs have causal effects on six outcomes, namely risks of esophageal varix, glaucoma, sleep apnea sy
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to serum lead accumulation Moderate
Carrier status is significantly associated with higher baseline and cumulative serum lead levels
Lifestyle
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high-lead-exposure sources and environments Moderate
Carriers accumulate serum lead more readily; cumulative exposure risk is elevated due to genetic predisposition
Minimize sources: old paint, water systems, occupational exposures, food sources
Screening
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serum lead levels Moderate
Genetic variant associated with elevated baseline serum lead accumulation
Check serum lead levels at baseline, then annually or as clinically indicated