rs10989661 - MTND3P4 - ARL2BPP7
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors - Unknown journal (n.d.) · Unknown authors · PubMed 19247474
ABSTRACT: The contribution of common genetic variation to one or more established smoking behaviors was investigated in a joint analysis of two genome wide association studies (GWAS) performed as part of the Cancer Genetic Markers of Susceptibility (CGEMS) project in 2,329 men from the Prostate, Lung, Colon and Ovarian (PLCO) Trial, and 2,282 women from the Nurses' Health Study (NHS). We analyzed seven measures of smoking behavior, four continuous (cigarettes per day [CPD], age at initiation of smoking, duration of smoking, and pack years), and three binary (ever versus never smoking, ≤10 versus >10 cigarettes per day [CPDBI], and current versus former smoking). Association testing for each single nucleotide polymorphism (SNP) was conducted by study and adjusted for age, cohabitation/mar
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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intensive smoking cessation support Low
rs10989661 minor allele is associated with reduced likelihood of smoking cessation, suggesting genetic predisposition to difficulty quitting
If currently smoking, discuss with doctor about intensive cessation strategies including counseling and medications