rs10988802 - PTCH1 - ERCC6L2-AS1

Magnitude 2.0 · 1 study on file

Reported associations

• Chemerin, a novel adipokine in the regulation of angiogenesis. - The Journal of clinical endocrinology and metabolism (2010) · Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB · PubMed 20237162

  Chemerin is a new adipokine associated with obesity and the metabolic syndrome. Gene expression levels of chemerin were elevated in the adipose depots of obese compared with lean animals and was markedly elevated during differentiation of fibroblasts into mature adipocytes. The objective of the study was to identify factors that affect the regulation and potential function of chemerin using a genetics approach. Plasma chemerin levels were measured in subjects from the San Antonio Family Heart Study, a large family-based genetic epidemiological study including 1354 Mexican-American individuals. Individuals were randomly sampled without regard to phenotype or disease status. A genome-wide association analysis using 542,944 single-nucleotide polymorphisms in a subset of 523 of the same subjec

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